生物活性

• 描述Oxymatrine, a quinolizidine alkaloid derived from the traditional Chinese herb Sophora flavescens Aiton, exhibits a wide range of pharmacological activities^[3].Oral oxymatrine preparation showed some potential benefits for patients with CHB(chronic hepatitis B)^[4].Moreover, hearts from those rats which were pre-treated with oxymatrine had significantly less evidence of apoptosis. Doxorubicin-induced increases in both the number of Hoechst positive cells and the amount of LDH leakage was attenuated by oxymatrine (50µg/mL) ^[5].
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT02202473	Chronic Hepatitis B	Phase 4	Completed	-	China, Jiangsu ... more >> the second hospital of Nanjing Nanjing, Jiangsu, China, 210000 Collapse <<
  NCT02239237	-	-	Completed	-	China, Hebei ... more >> HanDan Central Hospital HanDan, Hebei, China, 056001 Handan First Hospital Handan, Hebei, China, 056002 Bai Qiu'en International Peace Hospital Shijiazhuang, Hebei, China, 050082 China, Henan Henan University Huaihe Hospital Kaifeng, Henan, China, 475001 The First Affiliated Hospital of Henan University of Science & Technology Luoyang, Henan, China, 471000 Luoyang Central Hospital Affiliated to Zhengzhou University Luoyang, Henan, China, 471009 Xinxiang Central Hospital Xinxiang, Henan, China, 453000 The First Affiliated Hospital of Xinxiang Medical University Xinxiang, Henan, China, 453199 Xinyang Central Hospital Xinyang, Henan, China, 464000 People's Hospital of Zhengzhou Zhengzhou, Henan, China, 450003 Henan Cancer Hospital Zhengzhou, Henan, China, 450008 The First Hospital of Henan College of Traditional Chinese Medicine Zhengzhou, Henan, China, 451199 China, Shandong Shandong Provincial Western Hospital Jinan, Shandong, China, 250022 Qingdao Center Hospital Qingdao, Shandong, China, 266031 Tai'an Central Hospital Tai'an, Shandong, China, 271000 The 88th Hospital of People's Liberation Army Tai'an, Shandong, China, 271002 People's Hospital of Xintai City Tai'an, Shandong, China, 271200 Weifang No.2 People's Hospital Weifang, Shandong, China, 261041 Weihai Municipal Hospital Weihai, Shandong, China, 264299 Central Hospital of Zibo Zibo, Shandong, China, 255020 China, Shanxi Jincheng General Hospital Jincheng, Shanxi, China, 048006 The Fourth People's Hospital of Linfen Linfen, Shanxi, China, 041099 Traditional Chinese Hospital of Shanxi Taiyuan, Shanxi, China, 030012 Yuncheng Central Hospital Yuncheng, Shanxi, China, 044099 China, Sichuan Chengdu Second People's Hospital Chengdu, Sichuan, China, 610017 AVIC 363 Hospital Chengdu, Sichuan, China, 610041 Teaching Hospital of Chengdu University of T.C.M. Chengdu, Sichuan, China, 610072 The Second People's Hospital of Yibin Yibin, Sichuan, China, 644000 China, Tianjin Tianjin medical university cancer institute & hosptial Tianjin, Tianjin, China, 300060 Collapse <<

• 参考文献

• [1] Xiang X, Wang G, et al. Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis. Chin Med J (Engl). 2002 Apr;115(4):593-6.

  [2] Chen XS, Wang GJ, et al. Inhibition of hepatitis B virus by oxymatrine in vivo. World J Gastroenterol. 2001 Feb;7(1):49-52.

  [3] Zhang YY, Yi M, Huang YP. Oxymatrine Ameliorates Doxorubicin-Induced Cardiotoxicity in Rats. Cell Physiol Biochem. 2017;43(2):626-635. doi: 10.1159/000480471. Epub 2017 Sep 21. PMID: 28946137.

  [4] Song WJ, Luo J, Wu T, Yao SK. Oral oxymatrine preparation for chronic hepatitis B: A systematic review of randomized controlled trials. Chin J Integr Med. 2016 Feb;22(2):141-9. doi: 10.1007/s11655-015-2143-0. Epub 2015 May 26. PMID: 26016455.

  [5] Moreira MLM, Paula FJA. What Value is there in Assessing Postmenopausal Women for Vitamin D Deficiency? Rev Bras Ginecol Obstet. 2017 Nov;39(11):585-586. English. doi: 10.1055/s-0037-1606858. Epub 2017 Sep 25. PMID: 28946173.

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